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Description

A diabody comprises a heavy chain variable domain VH linked to a light chain variable domain VL in the same polypeptide chain

10.1210/jc.2018-01221 28 KalantarM.HosseiniS

doi: 10.3892/ol.2020.12137 173

Very recently, ISA was found to be a strong inhibitor of NLRP3, with IC 50 of 7.86 M in assays to assess the inhibition on IL-1 release induced by nigericin in THP-1 cells (Zhao et al., 2024)

Dose Range: 300500 mcg daily with gradual titration

Biochem J 199:649656 Li H, Low YSJ, Chong HP, Zin MT, Lee CY, Li B, Leolukman M, Kang L (2015) Microneedle-mediated delivery of copper peptide through skin